# Table 6 Day 7 DEAQ and LF blood concentrations by presence or absence of selected AEs, safety population, Study-T

Study-T

ASAQ

AL

(>5 years)

N = 496

N = 502

AEs of interest

Patients

DEAQ blood concentration

p-value

Patients

LF blood concentration

p-value

n/N*

[ng/ml] median (IQR)

**

n/N*

[ng/ml] median (IQR)

**

All patients

421/496

466 (352,606)

447/502

505 (I 380,670)

Fatigue (pool)

No AE

250/296

466 (352,605)

p = 0.925

376/421

504 (381,659)

p = 0.549

AE

171/200

466 (352,606)

71/81

519 (374,709)

Vomiting

No AE

393/461

461 (345,603)

p = 0.003

440/494

505 (381,670)

p = 0.711

AE

28/35

559 (467, 705)

7/8

463 (277, 828)

Nausea

No AE

407/480

466 (352, 605)

p = 0.754

443/497

505 (381, 670)

p = 0.111

AE

14/16

457 (387, 648)

4/5

245 (100, 549)

Anaemia

No AE

350/422

462 (352, 604)

p = 0.162

403/453

505 (381, 701)

p = 0.745

AE

71/74

517 (345, 677)

44/49

508 (374, 616)

Hepatotoxicity

No AE

402/473

465 (352, 606)

p = 0.512

418/471

506 (378, 681)

p = 0.882

AE

19/23

485 (407, 586)

29/31

477 (416, 659)

1. * n/N = number of blood samples available and quantifiable (n) among total patients with or without AE (N); ** Two-sample Wilcoxon rank-sum (Mann–Whitney) test.