Sample size calculation for multicentre efficacy trials of blood-stage malaria antigens

Malaria Journal

Table 2 The power for expected number of events required in the control group for a specific relative rate, θ, for the different scenarios as in Table1 using eqn ( 7)

Scenarios	Sample size	E(n)	Alpha	z_α/2	θ	E_c	z_β	Power
Scenario 1	1,840	339	0.05	1.96	0.7	199.412	1.2892	0.90
	1,288	237	0.05	1.96	0.7	139.412	0.75677	0.78
Scenario 2	1,840	322	0.05	1.96	0.7	189.412	1.20669	0.89
	1,288	226	0.05	1.96	0.7	132.941	0.69297	0.76
Scenario 3	1,840	237	0.05	1.96	0.7	139.412	0.75677	0.78
	1,288	166	0.05	1.96	0.7	97.6471	0.3137	0.62
Scenario 4	1,840	168	0.05	1.96	0.7	98.8235	0.32736	0.63
	1,288	117	0.05	1.96	0.7	68.8235	-0.05114	0.48
Scenario 5	1,380	237	0.05	1.96	0.7	139.412	0.75677	0.78
	966	166	0.05	1.96	0.7	97.6471	0.3137	0.62

ISSN: 1475-2875