Skip to main content

Table 2 Changes in pre-treatment frequencies of pfcrt and pfmdr1 haplotypes between 2003 and 2012 in eastern Sudan

From: Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan

pfcrt/ pfmdr1 allele

2003 %

2006 %

2012 %

p-value 2003/2006

CVIET

93[20] 90[52]

 

74.6

0. 000/ 0.080

CVMNK

10[52]

 

30.2

0. 010

CVMNK/CVIET

24[52]

 

4.8

0. 012

N86

14[52]

12.1[30]

40.3

0. 006/ 0. 0001

86Y

84[52]

85[30]

55.2

0. 006/ 0. 000

86 N/Y

2[52]

3[30]

4.5

0.629/0.691

184F

 

74[30]

80.6

0.165

184 Y/F

 

0[30]

4.5

0.074

1246Y

 

6[30]

0.0

0.755

1246 D/Y

 

3[30]

0.0

0.270

  1. p-values were calculated by comparing actual number of patients displaying each genotype from previous studies performed in Gedarif in 2003 [20, 52] and Gedarif and Kassala 2006 [30]) and the current study (Kassala) by Fishers exact test.