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Figure 1 | Malaria Journal

Figure 1

From: The design and statistical power of treatment re-infection studies of the association between pre-erythrocytic immunity and infection with Plasmodium falciparum

Figure 1

Schematic representation of a treatment re-infection study for measuring pre-erythrocytic immune responses. The solid black lines denote when samples are taken for a study with two cross-sections, and the dashed lines indicate when additional samples need to be taken for a longitudinal study. The difference between the cumulative proportion exposed to infection (green) and the cumulative proportion parasite positive (blue) is explained by pre-erythrocytic immunity and sporozoite inoculations that do not progress to blood-stage infection due to chance. The difference between the cumulative proportion parasite positive (blue) and the cumulative proportion with clinical malaria (red) is explained by blood-stage immunity.

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Malaria Journal

ISSN: 1475-2875

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