The design and statistical power of treatment re-infection studies of the association between pre-erythrocytic immunity and infection with Plasmodium falciparum

Table 1 Parameters for simulation of treatment re-infection studies

Description	Parameter	Value
Baseline transmission efficiency	b ₀	0.55
PE marker needed to prevent 50% of infections	α ₅₀	1
Mean in population with 30% protection	μ _α	0.56
Mean in population with 50% protection	μ _α	1.19
Coefficient of variation in PE marker	σ_α/μ_α	0.75
Duration of follow-up (weeks)	T	12
Low transmission EIR (ibppy)	ε	5
High transmission EIR (ibppy)	ε	150

Baseline transmission efficiency based on estimates from Smith et al. [16]. Pre-erythrocytic immune markers are given in arbitrary dimensionless units and are assumed to be Log-Normally distributed across a population.

ISSN: 1475-2875