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Table 2 IC50 values of commonly used anti-malarial drugs in in vitro culture of Plasmodium falciparum and in Plasmodium vivax from Manaus, Amazonas State, Brazil

From: Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon

 

P. falciparum

P. vivax

  

IC50 (nM)

 

IC50 (nM)

Drug1

No. of isolates

Geometric mean

95% CI2

Range

No of isolates

Geometric mean

95% CI2

Range

Chloroquine

64

361.8

266–492

9–3373

132

24.1

20–29

5–729

Quinine1

63

128.5

93–175

12–2174

-

-

-

-

Mefloquine

66

14.2

10–20

2–723

78

18.1

14–23

2–337

Artesunate1

51

3.4

3–4

0.3–52

-

--

--

-

  1. 1Performed only in P. falciparum cultures; 2CI, confidence interval.