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Table 1 Genetic polymorphism of MSP-3α in P. vivax and P. cynomolgi populations

From: Merozoite surface protein-3 alpha as a genetic marker for epidemiologic studies in Plasmodium vivax: a cautionary note

Species (Population) n Allele range Aligned lengthb Inform. sites Indel hap. Average indel length d(SE)c dS-dN(SE) Z-stat p value
P. vivax 48 1779-2601 2646 1413 28 67.3 0.027 (0.003) +0.021 (0.007) *
Worldwidea 21 1788-2601 2646 1572 15 46.3 0.027 (0.003) +0.025 (0.008) *
Thailand 17 1779-2580 2646 1686 13 100.8 0.033 (0.002) +0.024 (0.007) *
Venezuela 10 2232-2295 2646 2214 4 24.8 0.031 (0.002) +0.010 (0.005) -
P. cynomolgi 9 1959-1968 2028 1902 6 21.5 0.064 (0.004) +0.024 (0.010) *
  1. “Inform. sites” stands for “Informative sites” and “Indel Hap.” stands for “Indel Haplotypes”.
  2. “*” Indicates that the value is statistically significant for α = 0.05; “-” stands for non-significant.
  3. a The worldwide population of P. vivax contains the geographically diverse samples (n = 21) not within the Venezuelan or Thai sample populations from 2003-2004 or 2001-2002, respectively.
  4. b Lengths and allele range are in base pairs.
  5. c Diversity, d, is calculated as the average pairwise divergence per site. Standard error (SE) estimates from 1000 bootstrap pseudoreplications and p-values from the codon based Z test are shown. Significant values (p < 0.05) are bolded.