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Figure 5 | Malaria Journal

Figure 5

From: Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP142) administered intramuscularly with adjuvant system AS01

Figure 5

Results of serum GIA against Plasmodium falciparum FVO parasites for subjects receiving rabies vaccine and the 50 μg MSP1 42 (FVO)/AS01 vaccines in both Phase 1 studies. Percent parasite growth inhibition against the P. falciparum FVO clone parasites, comparing serum antibody responses obtained from Kenyan adults and US naïve subjects immunized with the 50 μg dose of MSP142 FVO/AS01. Left panel are the day 0 and post third immunization, day 70, responses from Kenya adults either receiving the rabies comparator control vaccine or the 50 μg dose of MSP142 FVO/AS01. Right panel are the net percent growth inhibitory responses for the US subjects receiving the 50 μg dose of MSP142 FVO/AS01. Dashed horizontal lines indicate median responses, while the filled lines indicate the 25 and 75% quartiles. Individual responses are represented as either filled circles for the Kenyan adults receiving the rabies vaccine, filled triangles for the Kenyan adults receiving the MSP142 FVO/AS01 vaccine or filled gray squares for the US naïve subjects receiving the 50 μg dose MSP142 FVO/AS01.

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Malaria Journal

ISSN: 1475-2875

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