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Table 2 Number (N) and prevalence (%) of pure/mixed pfcrt , pfmdr1 , pfdhfr and pfdhps mutant alleles conferring resistance to chloroquine and sulphadoxine-pyrimethamine in Plasmodium falciparum isolates from Pakistan

From: A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan

   Pure Mixed
Gene Allele or haplotype N (%) N (%)
pfcrt SVMNT/ K76T 171 (100) 0 (0)
pfmdr1 N86Y 6 (4) 28 (16)
  Y184F 0 (0) 43 (25)
  S1034C 0 (0) 0 (0)
  N1042D 0 (0) 165 (96)
  D1246Y 0 (0) 0 (0)
pfdhfr pfdhfr triple (N51I + C59R + S108N) 0 (0) 7 (4)
  pfdhfr double (N51I + S108N) 11 (6) 3 (2)
  pfdhfr double (C59R + S108N) 148 (87) 9 (5)
pfdhps pfdhps double (A437G + K540E) 4 (2) 77 (45)
  pfdhps A437G 103 (60) 3 (2)
  pfdhps K540E 6 (4) 131 (77)
  pfdhps A581G 5 (3) 66 (39)
pfdhfr + pfdhps pfdhfr + pfdhps (C59R + S108N + A437G) 88 (51) 6 (4)