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Table 1 Prevalence of multilocus genotypes and single nucleotide polymorphism in pvdhfr , pvdhps and pvmdr1 gene of P. vivax

From: Prevalence and patterns of antifolate and chloroquine drug resistance markers in Plasmodium vivax across Pakistan

Gene

Sample size

Haplotypes*

No of isolates (%)

pvdhfr

336

IPFSTSI (wild type)

151 (45)

IPFSTN I

100 (30)

IPFR TN I

76 (23)

IPLR TSI

5 (1.5)

IPFR TSI

3 (1.0)

IPFI TN I

1 (0.3)

pvdhps

339

SAKAV (wild type)

330 (97)

SG KAV

7 (2.0)

SAKG V

1 (0.3)

SG KG V

1 (0.3)

pvdhfr + pvdhps

322

IPFSTSISAKAV (wild type)

143 (44)

IPFSTN ISAKAV

95 (30)

IPFR TN ISAKAV

69 (21)

IPLR TSISAKAV

5 (1.6)

IPFR TSISAKAV

3 (1.0)

IPFSTN ISG KAV

2 (0.6)

IPFR TN ISG KAV

2 (0.6)

IPFSTSISAKG V

1 (0.3)

IPFSTSISG KAV

1 (0.3)

IPFR TN ISG KG V

1 (0.3)

pvmdr1

342

YF (wild type genotype)

7 (2.0)

YL (single mutant genotype)

335 (98)

F F (single mutant genotype)

0

  

FL (double mutant genotype)

0

  1. *Drug resistance conferring point mutations are shown for the following codons: pvdhfr 13, 33, 57, 58, 61, 117, 173; pvdhps 382, 383, 512, 553, 585; and pvmdr1 976, 1076. Mutated amino acids are shown in bold.