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Table 1 Prevalence of multilocus genotypes and single nucleotide polymorphism in pvdhfr , pvdhps and pvmdr1 gene of P. vivax

From: Prevalence and patterns of antifolate and chloroquine drug resistance markers in Plasmodium vivax across Pakistan

Gene Sample size Haplotypes* No of isolates (%)
pvdhfr 336 IPFSTSI (wild type) 151 (45)
IPFSTN I 100 (30)
IPFR TN I 76 (23)
IPLR TSI 5 (1.5)
IPFR TSI 3 (1.0)
IPFI TN I 1 (0.3)
pvdhps 339 SAKAV (wild type) 330 (97)
SG KAV 7 (2.0)
SAKG V 1 (0.3)
SG KG V 1 (0.3)
pvdhfr + pvdhps 322 IPFSTSISAKAV (wild type) 143 (44)
IPFSTN ISAKAV 95 (30)
IPFR TN ISAKAV 69 (21)
IPLR TSISAKAV 5 (1.6)
IPFR TSISAKAV 3 (1.0)
IPFSTN ISG KAV 2 (0.6)
IPFR TN ISG KAV 2 (0.6)
IPFSTSISAKG V 1 (0.3)
IPFSTSISG KAV 1 (0.3)
IPFR TN ISG KG V 1 (0.3)
pvmdr1 342 YF (wild type genotype) 7 (2.0)
YL (single mutant genotype) 335 (98)
F F (single mutant genotype) 0
   FL (double mutant genotype) 0
  1. *Drug resistance conferring point mutations are shown for the following codons: pvdhfr 13, 33, 57, 58, 61, 117, 173; pvdhps 382, 383, 512, 553, 585; and pvmdr1 976, 1076. Mutated amino acids are shown in bold.