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Table 2 Prevalence and distribution of pvdhfr , pvdhps and pvmdr1 alleles by province

From: Prevalence and patterns of antifolate and chloroquine drug resistance markers in Plasmodium vivax across Pakistan

  *pvdhfr pvdhps pvmdr1
  Haplotypes No of isolates (%) Haplotypes No of isolates (%) Haplotypes No of isolates (%)
Balochistan IPFSTSI (wild type) 19 (5.7) SAKAV (wild type) 44 (13) YF (wild type) 2 (0.6)
IPFSTN I 18 (5.4) SG KAV 1 (0.3) YL 38 (11)
IPFR TN I 6 (2)     
Total sequenced 43/50   45/50   40/50  
Islamabad IPFSTSI 26 (7.7) SAKAV 47 (14) YF 3 (1.0)
IPFR TN I 14 (4.2)    YL 47 (14)
IPFSTN I 10 (3.0)     
Total sequenced 50/50   47/50   50/50  
Khyber Pakhtunkhwa IPFSTSI 37 (11) SAKAV 108 (32) YF 5 (2.0)
IPFSTN I 50 (15) SAKG V 1 (0.3) YL 110 (32)
IPFR TN I 22 (6.5) SG KAV 4 (1.2)   
IPFR TSI 2 (0.6)     
IPLR TSI 1 (0.3)     
Total sequenced 112/119   113/119   115/119  
Punjab IPFSTSI 55 (16) SAKAV 89 (26) YF 5 (2.0)
IPFR TN I 12 (3.6) SG KAV 1 (0.3) YL 84 (25)
IPFSTN I 12 (3.6) SG KG V 1 (0.3)   
IPLR TSI 4 (1.2)     
IPFR TSI 1 (0.3)     
Total sequenced 84/103   91/103   89/103  
Sindh IPFSTSI 14 (4.2) SAKAV 42 (12) YF 2 (0.6)
IPFR TN I 23 (6.8) SG KAV 1 (0.3) YL 46 (14)
IPFSTN I 10 (3.0)     
Total sequenced 47/50   43/50   48/50  
  1. * Drug resistance-conferring point mutations are shown for the following codons: pvdhfr 13, 33, 57, 58, 61, 117, 173; pvdhps 382, 383, 512, 553, 585; and pvmdr1 976, 1076. Mutated amino acids are shown in bold.