Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice

Table 1 Epidemiological, haematological and biochemical parameters of healthy volunteers and vivax malaria patients with and without jaundice (total bilurubin > 51.3 μmol/L) on Day 1

	Healthy volunteers (n = 28)	*P. vivax* malaria without jaundice (n = 34)	*P. vivax* malaria with jaundice (n = 8)	P-value*
Age	25.4 ± 4.6	37.6 ± 15.2	33.5 ± 14.0	0.4867
Male sex (%)	32	82	38	0.0316
First malarial infection (%)	-	24	63	0.0316
Time of disease (in days)	-	6.5 ± 2.7	9.7 ± 7.9	0.3960
Peripheral parasitaemia/μL	-	2,428 ± 4,276	5,353 ± 10,598	0.3578
Leukocytes (×10³/μL)	6.69 ± 1.65	5.33 ± 1.59	5.41 ± 1.18	0.8903
Haemoglobin (g/dL)	13.0 ± 1.4	12.8 ± 1.8	10.8 ± 1.9	0.0051
Platelets (×10³/μL)	228.5 ± 62.0	93.7 ± 52.0	85.1 ± 54.2	0.6790
TB (μmol/L)	18.1 ± 8.5	26.3 ± 10.1	109.3 ± 81.9	< 0.0001
IB (μmol/L)	10.1 ± 6.2	15.7 ± 7.2	28.6 ± 15.2	0.0547
DB (μmol/L)	8.0 ± 6.7	10.6 ± 6.3	80.7 ± 79.3	0.0003
AST (U/L)	21.5 ± 8.9	34.5 ± 17.4	74.7 ± 67.1	0.0488
ALT (U/L)	16.4 ± 8.7	34.5 ± 27.0	93.0 ± 91.8	0.0420
AP (U/L)	57.6 ± 21.4	72.4 ± 28.0	103.9 ± 68.2	0.2408
Gamma-GT (U/L)	11.5 ± 5.5	45.7 ± 37.3	106.4 ± 92.1	0.2408
LDH (U/L)	255.6 ± 74.3	425.2 ± 188.5	609.7 ± 234.8	0.0294

TB total bilirubin, IB indirect bilirubin, DB direct bilirubin, AST aspartate aminotransferase, ALT alanine aminotransferase, AP alkaline phosphatase, gamma-GT gamma-glutamiltransferase, LDH lactate dehydrogenase.
*Comparison between vivax malaria patients with and without jaundice. Significant values in bold.
Continuous variables are presented as mean ± SD.

ISSN: 1475-2875