Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers

Table 1 List of Plasmodium falciparum strains/clones in current widespread use for in vitro studies

Strain/Clone^§	Origin	Region	Year reported*	Reference
Chloroquine sensitive
NF-54	Netherlands	Europe	1981	[9, 10]
3D7 (cloned from NF-54)	Netherlands	Europe	1987	[11]
D10 (cloned from FC27)	Papua New Guinea	Oceania	1983	[12]
HB3 (cloned from Honduras I/CDC)	Honduras	Central America	1984	[13]
D6 (cloned from Sierra Leone I/CDC)	Sierra Leone	Africa	1988	[14]
T9-96 (cloned from T9)	Thailand	Asia	1981	[15, 16]
GB4 (cloned from Ghana III/CDC)	Ghana	Africa	2003	[17]
ITG2F6 (cloned from Ituxi 084)	Brazil	South America	1979	[18]
Chloroquine resistant
K1	Thailand	Asia	1981	[19]
FCR3	The Gambia	Africa	1981	[20]
W2 (cloned from Indo III/CDC)	Indochina	Asia	1988	[14]
W2mef (derived from W2)	Indochina	Asia	1988	[21]
Dd2 (cloned from W2mef)	Indochina	Asia	1988	[22]
7G8 (cloned from IMTM22)	Brazil	South America	1984	[23]
V1/S (cloned from V1)	Vietnam	Asia	1990	[24]
Malayan Camp	Malaya	Asia	1965	[25]

^§This list is not meant to reflect an exhaustive reference of all the parasite lines in use world-wide and it excludes the multiple progeny of the HB3 × Dd2 genetic cross or the 7G8 × GB4 genetic cross. Instead, it represents a list of parasites that predominate in the literature still today in several genetic and drug sensitivity studies.
*These are the earliest literature reports for the parasite lines/clones listed so the actual date of establishment in culture pre-dates these references in each case.

ISSN: 1475-2875