Isolate | IC50values (nM) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Endoperoxides | 4-aminoquinolines | Arylaminoalcohols | Other | ||||||||
DHA | OZ277 | CQ | AQ | PIP | MQ | LUM | QUI | PND | ATV | PYR | |
HL1204 Kenya | 2.7 ± 0.4 | 0.5 ± 0.1 | 13 ± 2 | 3.6 ± 0.5 | 27 ± 4 | 20 ± 2 | 119 ± 17 | 42 ± 10 | 2.6 ± 0.5 | 0.7 ± 0.1 | >10000 |
HL1205 Nigeria | 3.6 ± 0.7 | 0.5 ± 0.1 | 149 ± 10 | 5.6 ± 0.5 | 21 ± 4 | 17 ± 1 | 105 ± 20 | 58 ± 7 | 3.6 ± 0.9 | 0.7 ± 0.1 | >10000 |
HL1209 South Sudan | 4.7 ± 0.6 | 1.5 ± 0.5 | 12 ± 1 | 6.7 ± 1.1 | 26 ± 3 | 36 ± 6 | 110 ± 23 | 60 ± 7 | 2.2 ± 0.8 | 0.2 ± 0.03 | >10000 |
HL1210 Ghana | 1.7 ± 0.3 | 1.1 ± 0.2 | 150 ± 7 | 7.4 ± 0.5 | 16 ± 2 | 7.7 ± 0.8 | 24 ± 6 | 156 ± 17 | 1.9 ± 0.5 | 0.4 ± 0.1 | >10000 |
HL1211 Ghana | 4.1 ± 0.3 | 1.1 ± 0.2 | 12 ± 1 | 5.8 ± 0.8 | 31 ± 7 | 27 ± 3 | 67 ± 18 | 50 ± 16 | 1.7 ± 0.2 | 0.3 ± 0.04 | >10000 |
HL1212 Nigeria | 3.3 ± 0.8 | 0.6 ± 0.09 | 12 ± 3 | 4.2 ± 1.2 | 27 ± 4 | 23 ± 3 | 91 ± 21 | 22 ± 4 | 2.6 ± 0.9 | 0.8 ± 0.04 | >10000 |
HL1214 Burkina Faso | 3.3 ± 0.7 | 0.6 ± 0.07 | 14 ± 3 | 4.2 ± 0.3 | 23 ± 7 | 23 ± 1 | 77 ± 28 | 52 ± 10 | 1.3 ± 0.6 | 0.7 ± 0.2 | 62 ± 25 |
Laboratory strains | |||||||||||
3D7 Netherlands | 5.5 ± 1.0 | 1.1 ± 0.3 | 15 ± 2 | 7.6 ± 1.7 | 14 ± 1 | 23 ± 3 | 73 ± 22 | 53 ± 6 | 5.0 ± 0.9 | 0.3 ± 0.2 | 28 ± 7 |
K1 Thailand | 5.2 ± 0.9 | 0.8 ± 0.3 | 374 ± 55 | 10 ± 3 | 37 ± 3 | 6.8 ± 2.9 | 32 ± 4 | 289 ± 40 | 16 ± 5 | 4.3 ± 1.0 | >10000 |