|
Isolate
|
IC50values (nM)
|
|---|
|
Endoperoxides
|
4-aminoquinolines
|
Arylaminoalcohols
|
Other
|
|---|
|
DHA
|
OZ277
|
CQ
|
AQ
|
PIP
|
MQ
|
LUM
|
QUI
|
PND
|
ATV
|
PYR
|
|---|
|
HL1204 Kenya
|
2.7 ± 0.4
|
0.5 ± 0.1
|
13 ± 2
|
3.6 ± 0.5
|
27 ± 4
|
20 ± 2
|
119 ± 17
|
42 ± 10
|
2.6 ± 0.5
|
0.7 ± 0.1
|
>10000
|
|
HL1205 Nigeria
|
3.6 ± 0.7
|
0.5 ± 0.1
|
149 ± 10
|
5.6 ± 0.5
|
21 ± 4
|
17 ± 1
|
105 ± 20
|
58 ± 7
|
3.6 ± 0.9
|
0.7 ± 0.1
|
>10000
|
|
HL1209 South Sudan
|
4.7 ± 0.6
|
1.5 ± 0.5
|
12 ± 1
|
6.7 ± 1.1
|
26 ± 3
|
36 ± 6
|
110 ± 23
|
60 ± 7
|
2.2 ± 0.8
|
0.2 ± 0.03
|
>10000
|
|
HL1210 Ghana
|
1.7 ± 0.3
|
1.1 ± 0.2
|
150 ± 7
|
7.4 ± 0.5
|
16 ± 2
|
7.7 ± 0.8
|
24 ± 6
|
156 ± 17
|
1.9 ± 0.5
|
0.4 ± 0.1
|
>10000
|
|
HL1211 Ghana
|
4.1 ± 0.3
|
1.1 ± 0.2
|
12 ± 1
|
5.8 ± 0.8
|
31 ± 7
|
27 ± 3
|
67 ± 18
|
50 ± 16
|
1.7 ± 0.2
|
0.3 ± 0.04
|
>10000
|
|
HL1212 Nigeria
|
3.3 ± 0.8
|
0.6 ± 0.09
|
12 ± 3
|
4.2 ± 1.2
|
27 ± 4
|
23 ± 3
|
91 ± 21
|
22 ± 4
|
2.6 ± 0.9
|
0.8 ± 0.04
|
>10000
|
|
HL1214 Burkina Faso
|
3.3 ± 0.7
|
0.6 ± 0.07
|
14 ± 3
|
4.2 ± 0.3
|
23 ± 7
|
23 ± 1
|
77 ± 28
|
52 ± 10
|
1.3 ± 0.6
|
0.7 ± 0.2
|
62 ± 25
|
|
Laboratory strains
|
|
3D7 Netherlands
|
5.5 ± 1.0
|
1.1 ± 0.3
|
15 ± 2
|
7.6 ± 1.7
|
14 ± 1
|
23 ± 3
|
73 ± 22
|
53 ± 6
|
5.0 ± 0.9
|
0.3 ± 0.2
|
28 ± 7
|
|
K1 Thailand
|
5.2 ± 0.9
|
0.8 ± 0.3
|
374 ± 55
|
10 ± 3
|
37 ± 3
|
6.8 ± 2.9
|
32 ± 4
|
289 ± 40
|
16 ± 5
|
4.3 ± 1.0
|
>10000
|
- The abbreviations for the antimalarial compounds are: dihydroartemisinin (DHA), arterolane, synthetic endoperoxide (OZ277), chloroquine (CQ), amodiaquine (AQ), piperaquine (PIP), mefloquine (MQ), lumefantrine (LUM), quinine (QUI), pyronaridine (PND), atovaquone (ATV) and pyrimethamine (PYR).
- The IC50 values are averaged from at least three independent experiments with some repeated on more than ten occasions. All data are presented as mean ± S.E.M. In several instances, the IC50 values for pyrimethamine exceeded the limits of detection for the concentration range adopted in the experiments and are thus reported as >10,000 nM.
