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Table 3 Sensitivity of the Plasmodium falciparum patient isolates to a panel of anti-malarial compounds

From: Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers

Isolate IC50values (nM)
Endoperoxides 4-aminoquinolines Arylaminoalcohols Other
DHA OZ277 CQ AQ PIP MQ LUM QUI PND ATV PYR
HL1204 Kenya 2.7 ± 0.4 0.5 ± 0.1 13 ± 2 3.6 ± 0.5 27 ± 4 20 ± 2 119 ± 17 42 ± 10 2.6 ± 0.5 0.7 ± 0.1 >10000
HL1205 Nigeria 3.6 ± 0.7 0.5 ± 0.1 149 ± 10 5.6 ± 0.5 21 ± 4 17 ± 1 105 ± 20 58 ± 7 3.6 ± 0.9 0.7 ± 0.1 >10000
HL1209 South Sudan 4.7 ± 0.6 1.5 ± 0.5 12 ± 1 6.7 ± 1.1 26 ± 3 36 ± 6 110 ± 23 60 ± 7 2.2 ± 0.8 0.2 ± 0.03 >10000
HL1210 Ghana 1.7 ± 0.3 1.1 ± 0.2 150 ± 7 7.4 ± 0.5 16 ± 2 7.7 ± 0.8 24 ± 6 156 ± 17 1.9 ± 0.5 0.4 ± 0.1 >10000
HL1211 Ghana 4.1 ± 0.3 1.1 ± 0.2 12 ± 1 5.8 ± 0.8 31 ± 7 27 ± 3 67 ± 18 50 ± 16 1.7 ± 0.2 0.3 ± 0.04 >10000
HL1212 Nigeria 3.3 ± 0.8 0.6 ± 0.09 12 ± 3 4.2 ± 1.2 27 ± 4 23 ± 3 91 ± 21 22 ± 4 2.6 ± 0.9 0.8 ± 0.04 >10000
HL1214 Burkina Faso 3.3 ± 0.7 0.6 ± 0.07 14 ± 3 4.2 ± 0.3 23 ± 7 23 ± 1 77 ± 28 52 ± 10 1.3 ± 0.6 0.7 ± 0.2 62 ± 25
Laboratory strains
3D7 Netherlands 5.5 ± 1.0 1.1 ± 0.3 15 ± 2 7.6 ± 1.7 14 ± 1 23 ± 3 73 ± 22 53 ± 6 5.0 ± 0.9 0.3 ± 0.2 28 ± 7
K1 Thailand 5.2 ± 0.9 0.8 ± 0.3 374 ± 55 10 ± 3 37 ± 3 6.8 ± 2.9 32 ± 4 289 ± 40 16 ± 5 4.3 ± 1.0 >10000
  1. The abbreviations for the antimalarial compounds are: dihydroartemisinin (DHA), arterolane, synthetic endoperoxide (OZ277), chloroquine (CQ), amodiaquine (AQ), piperaquine (PIP), mefloquine (MQ), lumefantrine (LUM), quinine (QUI), pyronaridine (PND), atovaquone (ATV) and pyrimethamine (PYR).
  2. The IC50 values are averaged from at least three independent experiments with some repeated on more than ten occasions. All data are presented as mean ± S.E.M. In several instances, the IC50 values for pyrimethamine exceeded the limits of detection for the concentration range adopted in the experiments and are thus reported as >10,000 nM.