Skip to main content

Table 4 Haplotypes of parasite markers associated with drug resistance

From: Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers

Isolate Sample Haplotype
Pfcrt Pfmdr1 Pfdhps Pfdhfr Pfmdr1
72-76 86, 184, 1034, 1042, 1246 431, 436, 437, 540, 581, 613 16, 50, 51, 59, 108, 140, 164 Gene copy number
  Wild type reference CVMNK NYSND ISAKAA ACNCSVI  
HL1204 Kenya Day 0 pre-treatment CVMNK / CVIET NFSND ISGEAA ACNRNVI 1
Day 1 post-treatment CVMNK / CVIET NFSND ISGEAA ACNRNVI 1
Culture-adapted CVMNK NFSND ISGEAA ACNRNVI 1
HL1205 Nigeria Day 0 pre-treatment CVIET NYSND IFAKAS ACIRNVI 1
Day 1 post-treatment CVIET NYSND IFAKAS / ISGKAA ACIRNVI 1
Culture-adapted CVIET NYSND IFAKAS ACIRNVI 1
HL1209 South Sudan Day 0 pre-treatment CVMNK / CVIET NFSND ISAKAA ACICNVI 1
Day 1 post-treatment CVMNK / CVIET NFSND ISAKAA ACICNVI 1
Culture-adapted CVMNK NFSND ISAKAA ACICNVI 1
HL1210 Ghana Day 0 pre-treatment CVIET YFSND ISGKAA ACNRNVI / ACIRNVI 1
Day 1 post-treatment CVIET YFSND ISGKAA ACNRNVI / ACIRNVI 1
Culture-adapted CVIET YFSND ISGKAA ACNRNVI / ACIRNVI 1
HL1211 Ghana Day 0 pre-treatment CVMNK NYSND IAGKAA ACIRNVI 1
Day 1 post-treatment CVMNK NYSND IAGKAA ACIRNVI 1
Culture-adapted CVMNK NFSND ISAKAA ACICNVI 1
*HL1212 Nigeria Day 0 pre-treatment CVMNK / CVIET NYSND / NFSND ISGKAA ACIRNVI 1
Culture-adapted CVMNK NFSND ISGKAA ACIRNVI 1
§HL1214 Burkina Faso Day 0 pre-treatment CVMNK NFSND ISGKAA ACNCSVI / ACNRNVI 1
Culture-adapted CVMNK NFSND ISGKAA ACNCSVI / ACNRNVI 1
  1. *No Day 1 post-treatment sample was obtained for HL1212.
  2. §No haplotype data was obtained for the Day 1 post-treatment sample most likely due to complete parasite clearance shortly after drug administration.
  3. For clarity, wild type haplotypes for each gene reported are highlighted in bold.