Malaria Journal

Table 4 Haplotypes of parasite markers associated with drug resistance

From: Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers

Isolate	Sample	Haplotype
		*Pfcrt*	*Pfmdr1*	*Pfdhps*	*Pfdhfr*	*Pfmdr1*
		72-76	86, 184, 1034, 1042, 1246	431, 436, 437, 540, 581, 613	16, 50, 51, 59, 108, 140, 164	Gene copy number
	Wild type reference	CVMNK	NYSND	ISAKAA	ACNCSVI
HL1204 Kenya	Day 0 pre-treatment	CVMNK / CVIET	NFSND	ISGEAA	ACNRNVI	1
	Day 1 post-treatment	CVMNK / CVIET	NFSND	ISGEAA	ACNRNVI	1
	Culture-adapted	CVMNK	NFSND	ISGEAA	ACNRNVI	1
HL1205 Nigeria	Day 0 pre-treatment	CVIET	NYSND	IFAKAS	ACIRNVI	1
	Day 1 post-treatment	CVIET	NYSND	IFAKAS / ISGKAA	ACIRNVI	1
	Culture-adapted	CVIET	NYSND	IFAKAS	ACIRNVI	1
HL1209 South Sudan	Day 0 pre-treatment	CVMNK / CVIET	NFSND	ISAKAA	ACICNVI	1
	Day 1 post-treatment	CVMNK / CVIET	NFSND	ISAKAA	ACICNVI	1
	Culture-adapted	CVMNK	NFSND	ISAKAA	ACICNVI	1
HL1210 Ghana	Day 0 pre-treatment	CVIET	YFSND	ISGKAA	ACNRNVI / ACIRNVI	1
	Day 1 post-treatment	CVIET	YFSND	ISGKAA	ACNRNVI / ACIRNVI	1
	Culture-adapted	CVIET	YFSND	ISGKAA	ACNRNVI / ACIRNVI	1
HL1211 Ghana	Day 0 pre-treatment	CVMNK	NYSND	IAGKAA	ACIRNVI	1
	Day 1 post-treatment	CVMNK	NYSND	IAGKAA	ACIRNVI	1
	Culture-adapted	CVMNK	NFSND	ISAKAA	ACICNVI	1
*HL1212 Nigeria	Day 0 pre-treatment	CVMNK / CVIET	NYSND / NFSND	ISGKAA	ACIRNVI	1
*HL1212 Nigeria	Culture-adapted	CVMNK	NFSND	ISGKAA	ACIRNVI	1
^§HL1214 Burkina Faso	Day 0 pre-treatment	CVMNK	NFSND	ISGKAA	ACNCSVI / ACNRNVI	1
^§HL1214 Burkina Faso	Culture-adapted	CVMNK	NFSND	ISGKAA	ACNCSVI / ACNRNVI	1

*No Day 1 post-treatment sample was obtained for HL1212.
^§No haplotype data was obtained for the Day 1 post-treatment sample most likely due to complete parasite clearance shortly after drug administration.
For clarity, wild type haplotypes for each gene reported are highlighted in bold.

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ISSN: 1475-2875

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