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Table 1 Anti-plasmodial activity data

From: Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis

 

Experimental IC50a(nM)

Experimental LD50a(nM)

Drug

HB3

Dd2

Rfb

HB3

Dd2

Rfb

CQ

23.8 (0.7)

212.3 (9.0)

9.0

120.0 (10.0)

15300.0 (900.0)

127.5

AQ

10.1 (0.6)

26.5 (0.4)

2.6

37.2 (1.2)

52.4 (2.3)

1.4

PQ

1990.0 (16.6)

4695.0 (62.1)

2.4

8640.0 (50.0)

2810.0 (10.0)

0.3

TQ

2189.9 (18.7)

2092.2 (20.0)

1.0

42700.0 (2042.6)

12100.0 (706.0)

0.3

MB

5.3 (0.09)

5.5 (0.07)

1.0

120.2 (9.5)

108.0 (6.6)

0.9

  1. aAverage of 3 independent measurements, each performed in triplicate (9 determinations total), with S.E.M. reported in parentheses.
  2. bResistance factor (Rf) = Dd2 value/HB3 value.