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Table 2 Organ-system classification and risk of adverse events in AL treated children

From: Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review

System organ class

Adverse event

Number of adverse events

Risk (per 1000 patients)

Gastrointestinal disorders

Abdominal pain

187

31.2

Anorexia

442

73.7

Diarrhoea

371

61.8

Nausea/vomiting

471

78.5

Others

109

18.2

General disorders

Weakness

372

62

Pyrexia

372

62

Mouth ulcer

13

2.2

Salivation

7

1.2

Unable to suck

5

0.8

Body pain

10

1.7

Hypersensitivity reaction

3

0.5

Puffy face

1

0.2

Respiratory disorders

Cough

1152

192

Coryza

449

74.8

Dyspnoea

4

0.7

Others

55

9.2

Central Nervous system disorders

Headache

228

38

Dizziness

18

3

Insomnia

23

3.8

Convulsion

3

0.5

Nystagmus

1

0.2

Skin and appendages disorders

Rash

55

9.2

Pruritus

90

15

Urticaria

2

0.3

Others

35

5.8

Haematological disorders

Anaemia

157

26.2

Haemolysis

3

0.5

Thrombocytopaenia

9

1.5

Neutropenia

42

7

Liver and biliary system disorders

Jaundice

3

0.5

Elevated ALT

23

3.8

Hepatomegaly

4

0.7

Musculo-skeletal system disorders

Joint pain

1

0.2

Cardiovascular disorders

Palpitation

6

1