Relative risk of AEs between AL and DP | |||||
---|---|---|---|---|---|
Adverse event | Risk AL (%) | Risk comparator (%) | Relative risk (95% CI) | P value (*significant) | References |
Vomiting | 10.3 | 9.7 | 0.99[0.86-1.13] | 0.85 | 15-24 |
Ç‚Anaemia | 3.7 | 10.1 | 0.45[0.20-1.02] | 0.05 | 18, 20 |
Abdominal pain | 10.9 | 10.4 | 1.31[0.99-1.73] | 0.06 | 17, 19, 21, 24 |
Diarrhoea | 13.3 | 12.6 | 1.03[0.89-1.20] | 0.65 | 15-18, 20-24 |
Pruritus | 5.8 | 4.5 | 1.28[0.81-2.02] | 0.30 | 17, 19, 21, 24 |
Weakness | 16.5 | 13.3 | 1.14[0.94-1.39] | 0.19 | 15, 17, 19, 21, 24 |
Cough | 39.8 | 39.2 | 0.99[0.92-1.05] | 0.65 | 15, 17-19, 20-22, 24 |
Anorexia | 12.3 | 11.0 | 1.07[0.93-1.24] | 0.38 | 15, 17, 19-22 |
SAE | 0.5 | 1.2 | 0.62[0.36-1.07] | 0.09 | 15-22 |
Relative risk of AEs between AL and ASAQ | |||||
Abdominal pain | 14.5 | 14.3 | 0.81[0.46-1.40] | 0.45 | 26, 28, 29, 31-34 |
Pruritus | 8.4 | 9.5 | 0.78[0.54-1.11] | 0.17 | 26, 28, 31, 34 |
Anorexia | 14.3 | 17.6 | 0.88[0.76-1.03] | 0.11 | 20, 26, 29, 31 |
Ç‚Anaemia | 8.9 | 19.1 | 0.61[0.19-1.90 | 0.39 | 20, 30, 31, 33 |
Headache | 13.5 | 7.9 | 1.29[0.89-1.87] | 0.17 | 29, 32, 34 |
Vomiting | 8.8 | 10.6 | 0.80[0.66-0.97] | *0.02 | 20, 26, 28-31, 33, 34 |
Weakness | 12.8 | 13.4 | 0.84[0.63-1.13] | 0.25 | 28, 29, 31, 34 |
Diarrhoea | 12.0 | 10.4 | 1.09[0.89-1.32] | 0.41 | 20, 27, 32, 34 |
Cough | 31.4 | 31.2 | 1.01[0.91-1.12] | 0.84 | 20, 27, 30, 32, 33 |
SAE | 0.8 | 1.5 | 0.54[0.27-1.05] | 0.07 | 20, 30-32 |
Relative risk of AEs between AL and ACD | |||||
Ç‚Anaemia | 2.8 | 7.2 | 0.35[0.09-1.43] | 0.15 | 26, 38 |
Anorexia | 11.8 | 17.8 | 0.80[0.63-1.00] | 0.05 | 20, 26 |
Cough | 29.2 | 23.0 | 1.13[0.96-1.34] | 0.15 | 20, 26 |
Diarrhoea | 6.0 | 8.6 | 1.28[0.96-1.73] | 0.11 | 20, 26 |
Vomiting | 1.2 | 5.2 | 0.63[0.47-0.85] | *0.002 | 20, 26, 38 |
SAE | 1.3 | 5.2 | 0.45[0.27-0.74] | *0.002 | 26, 38 |
Relative risk of AEs between AL and AM | |||||
Weakness | 64.9 | 58.2 | 1.12[1.04-1.21] | *0.004 | 39, 40 |
Abdominal pain | 1.7 | 3.8 | 0.44[0.14-1.41] | 0.17 | 39, 40 |
Vomiting | 21.3 | 22.8 | 0.75[0.27-2.05] | 0.57 | 39, 40 |