Skip to main content

Table 3 Relative risk of AEs between AL and other artemisinin-based combinations

From: Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review

Relative risk of AEs between AL and DP

Adverse event

Risk AL (%)

Risk comparator (%)

Relative risk (95% CI)

P value (*significant)

References

Vomiting

10.3

9.7

0.99[0.86-1.13]

0.85

15-24

Ç‚Anaemia

3.7

10.1

0.45[0.20-1.02]

0.05

18, 20

Abdominal pain

10.9

10.4

1.31[0.99-1.73]

0.06

17, 19, 21, 24

Diarrhoea

13.3

12.6

1.03[0.89-1.20]

0.65

15-18, 20-24

Pruritus

5.8

4.5

1.28[0.81-2.02]

0.30

17, 19, 21, 24

Weakness

16.5

13.3

1.14[0.94-1.39]

0.19

15, 17, 19, 21, 24

Cough

39.8

39.2

0.99[0.92-1.05]

0.65

15, 17-19, 20-22, 24

Anorexia

12.3

11.0

1.07[0.93-1.24]

0.38

15, 17, 19-22

SAE

0.5

1.2

0.62[0.36-1.07]

0.09

15-22

Relative risk of AEs between AL and ASAQ

Abdominal pain

14.5

14.3

0.81[0.46-1.40]

0.45

26, 28, 29, 31-34

Pruritus

8.4

9.5

0.78[0.54-1.11]

0.17

26, 28, 31, 34

Anorexia

14.3

17.6

0.88[0.76-1.03]

0.11

20, 26, 29, 31

Ç‚Anaemia

8.9

19.1

0.61[0.19-1.90

0.39

20, 30, 31, 33

Headache

13.5

7.9

1.29[0.89-1.87]

0.17

29, 32, 34

Vomiting

8.8

10.6

0.80[0.66-0.97]

*0.02

20, 26, 28-31, 33, 34

Weakness

12.8

13.4

0.84[0.63-1.13]

0.25

28, 29, 31, 34

Diarrhoea

12.0

10.4

1.09[0.89-1.32]

0.41

20, 27, 32, 34

Cough

31.4

31.2

1.01[0.91-1.12]

0.84

20, 27, 30, 32, 33

SAE

0.8

1.5

0.54[0.27-1.05]

0.07

20, 30-32

Relative risk of AEs between AL and ACD

Ç‚Anaemia

2.8

7.2

0.35[0.09-1.43]

0.15

26, 38

Anorexia

11.8

17.8

0.80[0.63-1.00]

0.05

20, 26

Cough

29.2

23.0

1.13[0.96-1.34]

0.15

20, 26

Diarrhoea

6.0

8.6

1.28[0.96-1.73]

0.11

20, 26

Vomiting

1.2

5.2

0.63[0.47-0.85]

*0.002

20, 26, 38

SAE

1.3

5.2

0.45[0.27-0.74]

*0.002

26, 38

Relative risk of AEs between AL and AM

Weakness

64.9

58.2

1.12[1.04-1.21]

*0.004

39, 40

Abdominal pain

1.7

3.8

0.44[0.14-1.41]

0.17

39, 40

Vomiting

21.3

22.8

0.75[0.27-2.05]

0.57

39, 40

  1. Ç‚ Random effect model.
  2. * (<0.05) statistically significant’.