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Figure 3 | Malaria Journal

Figure 3

From: Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response

Figure 3

IFNα/β and IL-4 centred pathway analysis. A IFN-αβ centred pathway analysis. Network analysis was performed by using IFN-α and IFN-β as the central nodes. This study used software to select IFN-α or IFN-β related genes from the gene list. 24 IFN-α or IFN-β related genes were selected. Red entities mean proteins. Green entities mean small molecules including phospholipids and drugs. Hexon means groups of family proteins. A---B means A binds to B to form a complex. A- → B means A binds B’s promoter region to up-regulate B. A-- + - > B means A induces B release. A---|B means A causes B’s degradation or inhibition. Little square in the middle of the line means there is a third molecule which regulates the conversion from A to B. B IL-4 centred pathway analysis. Network analysis was performed by using IL-4 as the central nodes. This study used software to select IL-4 related genes from the gene list. Only four IL-4 related genes were selected.

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