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Table 1 Essential characteristics of screening assays for novel compounds effective against the different stages of malaria parasite life cycle

From: CRIMALDDI: platform technologies and novel anti-malarial drug targets

Robust

Ensures that screens are easy to perform, low cost, suitable for screening a large variety of chemotypes or natural products.

Validated

Ensures that the results reflect well the activity of the compound against the targeted parasite stage.

Reproducible

Ensures that the results obtained from different laboratories are directly comparable.

Representative of human malaria

Ensures that the results actually reflect the probable action of the compound(s) when used to treat human malaria.