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Table 3 Existing in vitro and in vivo models against liver stage parasites

From: CRIMALDDI: platform technologies and novel anti-malarial drug targets

 

In vitro

In vivo

Human

 

pharmacology

pharmacology

pharmacology

 

(HTS Screens)

  

Plasmodium that do not form hypnozoites

•  P. falciparum

Mouse models

Human challenge

•  P. berghei

•  P. berghei

•  P. yoelii

•  P. yoelii

Hypnozoites –forming Plasmodium species

•  P. vivax in hepatocyte cell lines

Primate models

 

•  P. cynomolgi

•  P. cynomolgi in hepatocytes from Rhesus monkeys