Table 5 Digestive adverse drug reactions under atovaquone-proguanil

Sex

Male

306

74

(24.2)

1

0.82

Female

163

41

(25.1)

0.9

[0.6 - 1.4]

Age

≤ 30

131

39

(29.8)

1

0.36

31-40

129

27

(20.9)

0.6

[0.3 - 1.1]

41-50

121

30

(24.8)

0,8

[0.4 - 1.3]

> 50

88

19

(21.6)

0.6

[0.3 - 1.2]

Origin

African

415

92

(22.2)

1

<0.01

1

0.19

European

43

16

(37.2)

2.1

[1.0 - 4.0]

1.2

[0.5 - 2.8]

Others

11

7

(63.6)

6.1

[1.7 - 21.4]

3.5

[0.9 - 14.0]

Immunity

Non immune

233

60

(25.7)

1

0.54

Semi-immune

236

55

(23.3)

0.88 [06 – 1.3]

Nausea at presentation

No

329

82

(24.9)

1

0.76

Yes

140

33

(23.6)

0.93 [0.58 – 1.48]

Chronic illness

No

425

105

(24.7)

1

0.77

Yes

44

10

(22.7)

0,9

[0.4 - 1.9]

Chemoprohylaxis

No

192

50

(26.0)

1

0.51

Yes

277

65

(23.5)

0.9

[0.6 - 1.3]

Type of travel

VFR*

378

80

(21.2)

1

< 0.01

1

< 0.01

Hostel

10

4

(40.0)

2.5

[0.7 - 9.0]

2.8

[0.8 - 10.4]

Backpackers

30

15

(50.0)

3.7

[1.7 - 7.9]

3.8

[1.8 - 8.2]

Unknown

51

16

(31.4)

1.7

[0.9 - 3.2]

1.7

[0.9 - 3.9]

Parasitaemia at diagnosis

≤ 0.10%

144

27

(18.7)

1

0.29

1

0.26

0.11 - 0.50%

148

42

(28.4)

1.7

[1.0 - 3.0]

1.8

[1.0 - 3.1]

0.51 - 1.00%

52

11

(21.2)

1.2

[0.5 - 2.5]

1.3

[0.6 - 2.9]

> 1%

90

25

(22.8)

1.7

[0.9 - 3.1]

1.9

[1.0 - 3.5]

Unknown

35

10

(28.6)

1.7

[0.7 - 4.0]

1.8

[0.7 - 4.2]

Parasitaemia at day 3

Negative

290

72

(24.8)

1

0.97

Positive

128

31

(24.2)

0.9

[0.6 - 1.6]

Unknown

51

12

(23.5)

0.9

[0.5 - 1.9]