Table 3 Prevalence of CR1 alleles and genotypes at four loci; Kn, McC, Sl and KCAM
Frequency of the genotypes n (%) | Controls (n = 275) | Uncomplicated malaria (n = 89) | Severe anaemia (n = 57) | Cerebral malaria (n = 121) | |
|---|---|---|---|---|---|
Kn a/b | a/a | 275 (100) | 88 (98.9) | 57 (100) | 120 (99.2) |
SNP Rs41274768 | a/b | 0 (0) | 1 (1.1) | 0 (0) | 1 (0.8) |
b/b | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
Allele frequency Kn b | 0.0 | 0.006 | 0.0 | 0.004 | |
McC a/b | a/a | 147 (53.5) | 52 (58.4 %) | 30 (52.6) | 68 (56.2) |
SNP Rs17047660 | a/b | 109 (39.6) | 26 (29.2) | 21 (36.8) | 42 (34.7) |
b/b | 19 (6.9) | 11 (12.4) | 6 (10.5) | 11 (9.1) | |
Allele frequency McC b | 0.27 | 0.27 | 0.29 | 0.27 | |
Sl1/Sl2 | 1/1 | 15 (5.5) | 2 (2.2) | 5 (8.8) | 8 (6.6) |
SNP Rs17047661 | 1/2 | 74 (26.9) | 14 (15.7) | 13 (22.8) | 24 (19.8) |
2/2 | 186 (67.6) | 73 (82.0) | 39 (68.4) | 89 (73.6) | |
Allele frequency Sl2 | 0.81 | 0.90 | 0.80 | 0.83 | |
KCAM +/- | +/+ | 5 (1.8) | 0 (0) | 0 (0) | 0 (0) |
SNP Rs6691117 | +/- | 45 (16.4) | 10 (11.2) | 8 (14.0) | 24 (19.8) |
-/- | 225 (81.8) | 79 (88.8) | 49 (86.0) | 97 (80.2) | |
Allele frequency KCAM - | 0.90 | 0.94 | 0.93 | 0.90 | |