Malaria Journal

Table 5 Haplotype frequencies of the four SNPs in the CR1 gene, determined in Ghanaian and Brazilian study populations

From: Human genetic polymorphisms in the Knops blood group are not associated with a protective advantage against Plasmodium falciparum malaria in Southern Ghana

Disease group (alleles)	Haplotype definitions
Disease group (alleles)	H1 Kn^aMcC^aSl1 KCAM⁺	H2 Kn^aMcC^aSl1 KCAM^-	H3 Kn^aMcC^aSl2 KCAM^-	H4 Kn^aMcC^bSl1 KCAM^-	H5 Kn^aMcC^bSl2 KCAM^-	H6 Kn^aMcC^bSl2 KCAM⁺	H7 Kn^aMcC^aSl2 KCAM⁺	H8 Kn^bMcC^aSl1 KCAM^-
Controls (n = 448)	0.02	0.10	0.59	0.00	0.24	0.01	0.03	0.00
Uncomplicated malaria (n = 163)	0.01	0.07	0.63	0.00	0.28	0.00	0.02	0.00
Severe anaemia (n = 98)	0.04	0.11	0.56	0.00	0.28	0.00	0.01	0.00
Cerebral malaria (n = 205)	0.03	0.08	0.60	0.00	0.25	0.00	0.03	0.00
Ghana (n = 914)	0.02	0.09	0.60	0.00	0.25	0.003	0.03	0.00
African Brazilians ¹ (n = 86)	0.14	0.15	0.42	0.12	0.07	0.070	0.023	0.11
European Brazilians ¹ (n = 66)	0.73	0.15	0.015	0.00	0.015	0.00	0.00	0.015
Asian Brazilians ¹ (n = 84)	0.79	0.21	0.00	0.00	0.00	0.00	0.00	0.00

¹Covas et al.[27] SNPs at the four loci Kn, McC, Sl and KCAM can define eight different haplotypes. There was no difference between the disease groups in the Ghanaian population with H3 and H5 having the highest frequencies, while H4 and H8 were not found. The Ghanaian groups were also compared to the three Brazilian populations. All differed significantly from Ghana p < 0.001. When constructing the haplotypes, individuals heterozygote at more than one locus was excluded from the analysis (15 %, n = 82).
a/b, 1/2 and +/– denotes the alleles at the four loci.

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