Table 2 Therapeutic responses of patients in Yunnan Province, China

Fever clearance times (hr)

   Mean (± SD)

26.9 (8.2)

39.8 (11.4)

<0.0001

   Range

12-72

17-64

No. with asexual parasitaemia on day 1 (24 hr)

25 (19.7%; 95%CI, 13.2-27.7%)

76 (59.4%; 95%CI, 50.3-68.0%)

<0.0001

0.397 (95%CI, 0.281-0.498)

No. with asexual parasitaemia on day 2 (48 hr)

25 (19.7%; 95%CI, 13.2-27.7%)

58 (45.3%; 95%CI, 36.5-54.3%)

<0.0001

0.256 (95%CI, 0.142-0.361)

50% parasite clearance times (hr)

   Mean (± SD)

8.3 (2.4)

12.8 (6.9)

0.023

   Range

7-17

8-32

Parasite clearance times (hr)

   Mean (± SD)

26.0 (5.6)

37.4 (11.9)

<0.0001

   Range

15-48

15-64

Gametocyte clearance times

   Mean (± SD)

26.7 (7.5)

36.2 (12.5)

<0.0001

   Range

8-48

8-64

Proportion of patients free of recurrence by day 28

127 (100%; 95%CI, 97.1-100%)

128 (100%; 95%CI, 97.2-100%)

-

0 (95%CI, -0.029-0.029)

Proportion of patients free of recurrence by day 42

125 (98.4%; 95%CI, 94.4-99.8%)

123 (96.1%; 95%CI, 91.1-98.7%)

0.4496

0.0233 (95%CI, -0.022-0.074)

Proportion of patients free of recurrence by day 365

101 (79.5%; 95%CI,71.8-85.9%)

106 (82.8%; 95%CI, 75.1-88.9%)

0.610

0.0328 (95%CI, -0.064-0.129)