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Figure 1 | Malaria Journal

Figure 1

From: Cytoplasmic free Ca2+ is essential for multiple steps in malaria parasite egress from infected erythrocytes

Figure 1

Free calcium kinetics in schizonts approaching parasite egress. Cells labelled with Fluo-4 AM (5 μM), and monitored at 37°C in full medium (A) or full medium supplemented with 40 μM probenecid (B). Selected frames from the time-lapse movies on the right side of each graph show DIC and fluorescence images of pre-egress schizonts (upper set of images), pre-egress schizonts with the erythrocyte membrane permeable to external calcium (middle set of images labelled as ‘poration’ showing the highest level of fluorescence signal) and lower set of images captured erythrocyte membrane rupture and parasite egress. Bar = 5 μm.

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