Figure 2

Relative difference (%) in half-life between alternative schedules A1-A4 and the reference dataset (six-hourly sampling), using actual study data. See Table 1 for a list of 13 included studies. Boxplots show the median, interquartile range and range. Panels A, B, C and D correspond to HLs less than 2 hours, between 2-3 hours, between 3-4 hours and more than 4 hours, respectively.