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Table 1 Summary of the 13 included studies

From: Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives

Country Years Number patients Sampling schedule Counting method DLM Reference
Thick (WBC) Thin (RBC)  
Thailand1 2001-2010 3391 SS1 500 1000 16 Phyo et al.[20]
Thailand2 2008 40 SS3 200 1000 16 Dondorp et al.[4]
Thailand3 2009-2010 80 SS2 200 1000 16 Das et al.[21]
Mali 2010 261 SS1 300 ND 25 Lopera-Mesa et al.[19]
Cambodia1 2007-2008 59 SS2 200 1000 16 Dondorp et al.[4]
Cambodia2 2008-2010 79 SS2 200 1000 16 Das et al.[21]
Cambodia3 2009 79 SS1 200 ND 15 Amaratunga et al.[18]
Cambodia4 2010 98 SS1 200 ND 15 Amaratunga et al.[18]
Cambodia5 2010 30 SS1 200 ND 15 Amaratunga et al.[18]
Cambodia6 2010 55 SS1 200 ND 15 Unpublished
Cambodia7 2008-2009 143 SS2 200 5000 14 Bethell et al.[24]
Kenya 2010-2011 171 SS2    30 Unpublished
Vietnam 2010-2011 166 SS1 400 1000 8 Hien et al.[25]
Total   4652      
  1. SS1 = six-hourly until negative; SS2 = zero, two, four, six, eight and 12 hours, and then six-hourly until negative; SS3 = zero, four, eight and 12 hours, and then six-hourly until negative; ND = not done; DLM = detection limit of microscopy (in parasites per μL); RBC = red blood cells; WBC = white blood cells.