Schedule

Prop OE (of 2746 profiles)

(IQR)

CV (%)

Std dev log(HL)

Prop NZ tlag

Median (IQR) NZ tlag

Prop tail

Prop (%) profiles misclassified, with HL cutoff of:


3 h

4 h

5 h

6 h


Ref

0%

0 (0–0)

54.5

0.52

26.5 (n = 729)

6 (6–6.25)

34% (n = 933)

0

0

0

0

A1

49.9%

0.01 (0.150.21)

51.6

0.503

22.1 (n = 606)

6 (6–6.27)

9.36% (n = 257)

7.7

3.9

2.7

2.2

A2

60.2%

0.06 (0.100.29)

51.1

0.482

17.4 (n = 478)

6 (6–6.03)

9.87% (n = 271)

8.6

4.4

3

2.2

A3

59.8%

0.09 (0.090.34)

50.9

0.484

12.5 (n = 344)

12 (12–12)

9.91% (n = 272)

9.5

4.5

3

2.1

A4

66.3%

0.15 (0.060.46)

47.7

0.435

6.96 (n = 191)

12 (12–12)

9.25% (n = 254)

10

4.6

3.4

2.2

 For each of the reference and alternative schedules (A1A4) applied to real patient data: the proportion of profiles that overestimate the HL (relative to the reference HL); median difference in HL (IQR); coefficient of variation of HL (CV) as a percentage; standard deviation of log (HL); the proportion of profiles with a nonzero lag phase (tlag); the median (IQR) tlag for profiles with a nonzero tlag; the proportion of profiles with a tail and the proportions of profiles that are misclassified when the HL estimates are dichotomized using HL cutoffs of three, four, five and six hours. IQR = interquartile range; Ref = reference; OE = overestimation (proportion of HLs from alternative schedule which exceeded reference HL); NZ = nonzero; prop = proportion.