TY - JOUR AU - Howes, Rosalind E. AU - Dewi, Mewahyu AU - Piel, Frédéric B. AU - Monteiro, Wuelton M. AU - Battle, Katherine E. AU - Messina, Jane P. AU - Sakuntabhai, Anavaj AU - Satyagraha, Ari W. AU - Williams, Thomas N. AU - Baird, J. Kevin AU - Hay, Simon I. PY - 2013 DA - 2013/11/15 TI - Spatial distribution of G6PD deficiency variants across malaria-endemic regions JO - Malaria Journal SP - 418 VL - 12 IS - 1 AB - Primaquine is essential for malaria control and elimination since it is the only available drug preventing multiple clinical attacks by relapses of Plasmodium vivax. It is also the only therapy against the sexual stages of Plasmodium falciparum infectious to mosquitoes, and is thus useful in preventing malaria transmission. However, the difficulties of diagnosing glucose-6-phosphate dehydrogenase deficiency (G6PDd) greatly hinder primaquine’s widespread use, as this common genetic disorder makes patients susceptible to potentially severe and fatal primaquine-induced haemolysis. The risk of such an outcome varies widely among G6PD gene variants. SN - 1475-2875 UR - https://doi.org/10.1186/1475-2875-12-418 DO - 10.1186/1475-2875-12-418 ID - Howes2013 ER -