From: Spatial distribution of G6PD deficiency variants across malaria-endemic regions
Type | Residual enzyme activity | Population-level prevalence | Clinical significance | Primaquine-associated public health concern |
---|---|---|---|---|
Type 1 | <10% | Sporadic (never polymorphic) | Severe and chronic: CNSHA | None – too rare |
Type 2§ | <1-50% | Polymorphic | Asymptomatic until exposed to an exogenous trigger | Yes – commonly inherited and cause individuals to be at risk of haemolysis |
Type 3 | Normal (>50%) | Polymorphic (wild-type) | None | None – G6PD normal |