Induction of pro-inflammatory response of the placental trophoblast by Plasmodium falciparum infected erythrocytes and TNF

Table 1 Adherence specificity of Plasmodium falciparum strains of different geographical origin selected to CSA

Parasite strain	IEs per 500 nuclei		% Inhibition	p Value
	Soluble CSA
	-	+
FCB1	267 ± 35	28 ± 3	88 ± 1,9	< 0,0001
FCB2	39 ± 5	15 ± 3	60 ± 7,9	0,0044
FCR3	36 ± 7	7 ± 1	72 ± 9,6	0,0018
3D7	27 ± 3	12 ± 2	54 ± 7,6	0,0077
FCB1csa	1569 ± 133	75 ± 18	95 ± 0,9	< 0,0001
FCB2csa	337 ± 33	32 ± 4	91 ± 0,7	< 0,0001
FCR3csa	100 ± 12	7 ± 4	94 ± 2,8	< 0,0001
3D7csa	595 ± 86	19 ± 8	97 ± 0,8	< 0,0001

Selected strains were incubated with soluble CSA (100 μg/mL) or adhesion medium for 30 min before the cytoadherence assay. The number of adhered IEs to 500 nuclei was quantified, and the inhibition percentage of adherence was estimated. The data represent the mean ± SEM of three independent experiments performed in duplicate (n = 6), t-student for comparison of control vs CSA treatment.

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