Compound | Assay 1 (A1): | Conclusion A1 | Assay 2 (A2): | Conclusion A2 | Concluded speed of action |
---|---|---|---|---|---|
 | IC50 speed assay |  | Stage specificity analysis |  |  |
 | (ratio of IC50 24 h/IC50 72 h)a |  | (at 6-100x IC50) |  |  |
Chloroquine | 1.1 | Fast | >95% action on Rb | Fast (cidal) | Fast (cidal) |
 |  |  | >95% action on Sb |  |  |
Artesunate | 1.1 | Fast | >95% action on R | Fast (cidal) | Fast (cidal) |
 |  |  | >95% action on S |  |  |
Atovaquone | 3.6 | Not fast | ~50-70% action on R | Not fast (cidal) | Not fast (cidal) |
 |  |  | ~75-90% action on S |  |  |
Pyrimethamine | 8.3 | Not fast | ~5% action on R | Not fast (cidal) | Not fast (cidal) |
 |  |  | ~90% action on S |  |  |
1 | 4.3 | Not fast | ~0-75% action on R | Not fast (cidal) | Not fast (cidal) |
 |  |  | >95% action on S |  |  |
2 | 1.6 | Fast/Not fast | ~40- >95% action on R | Not fast (cidal) | Not fast |
 |  |  | >95% action on S |  |  |
3 | 1.2 | Fast | >95% action on R | Fast (cidal) | Fast (cidal) |
 |  |  | >95% action on S |  |  |