In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains

Table 1 In vitro anti-malarial activity of semi-synthetic artemisinins, synthetic OZ277 and thapsigargin against Plasmodium falciparum K1 and NF54 strains

Compounds	Inhibitory concentrations (ng/ml)
	⁺P. falciparum K1		⁺P. falciparum NF54
	(Mean ± SE)		(Mean ± SE)
	IC₅₀	IC₉₀	IC₅₀	IC₉₀
Artesunate	0.60 ± 0.18	1.8 ± 0.1	0.98 ± 0.48	1.9 ± 1.1
Artemether	0.45 ± 0.28	0.80 ± 0.34	0.49 ± 0.18	0.98 ± 0.27
OZ277	0.17 ± 0.03	0.42 ± 0.11	0.82 ± 0.09	1.6 ± 0.4
Thapsigargin	1612 ± 140	6850 ± 730	1940 ± 433	7455 ± 2307

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