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Table 2 Parasite drug responses measured in the DAPI ex vivo assay

From: Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal

  2008 2009 2010 2011
(N = 86) (N = 78) (N = 81) (N = 82)
Amodiaquine
 Median IC50 9.6 6.5 11.2 14.5
 IC50 Range 1.6, 1140 3.2, 36.7 1.0, 45.3 2.3, 53.7
 90th percentile IC50 24.0 11.8 22.2 35.4
Artemisinin
 Median IC50 3.2 8.1 9.9 10.1
 IC50 Range 1.1, 28.8 1.8, 36.7 1.9, 38.0 1.3, 73.1
 90th percentile IC50 9.3 17.0 22.4 24.9
Chloroquine
 Median IC50 30.7 15.0 22.4 76.1
 IC50 Range 1.4, 341.5 4.3, 205.5 8.1, 430.2 4.7, 455.0
 90th percentile IC50 199.4 108.2 199.1 364.6
Mefloquine
 Median IC50 34.5 44.6 32.6 41.2
 IC50 Range 1.6, 398.0 2.8, 92.1 9.2, 75.7 1.5, 191.5
 90th percentile IC50 84.6 62.5 59.0 82.4
  1. IC50 values are in nM. IC50 Range = minimum IC50, maximum IC50. 90th percentile IC50 = IC50 value of the 90th percentile within the range of drug responses observed each year.
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Malaria Journal

ISSN: 1475-2875

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