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Table 2 Parasite drug responses measured in the DAPI ex vivo assay

From: Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal

 

2008

2009

2010

2011

(N = 86)

(N = 78)

(N = 81)

(N = 82)

Amodiaquine

 Median IC50

9.6

6.5

11.2

14.5

 IC50 Range

1.6, 1140

3.2, 36.7

1.0, 45.3

2.3, 53.7

 90th percentile IC50

24.0

11.8

22.2

35.4

Artemisinin

 Median IC50

3.2

8.1

9.9

10.1

 IC50 Range

1.1, 28.8

1.8, 36.7

1.9, 38.0

1.3, 73.1

 90th percentile IC50

9.3

17.0

22.4

24.9

Chloroquine

 Median IC50

30.7

15.0

22.4

76.1

 IC50 Range

1.4, 341.5

4.3, 205.5

8.1, 430.2

4.7, 455.0

 90th percentile IC50

199.4

108.2

199.1

364.6

Mefloquine

 Median IC50

34.5

44.6

32.6

41.2

 IC50 Range

1.6, 398.0

2.8, 92.1

9.2, 75.7

1.5, 191.5

 90th percentile IC50

84.6

62.5

59.0

82.4

  1. IC50 values are in nM. IC50 Range = minimum IC50, maximum IC50. 90th percentile IC50 = IC50 value of the 90th percentile within the range of drug responses observed each year.
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Malaria Journal

ISSN: 1475-2875

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