Table 1 Correlation of circulating Ang-Tie-2 concentrations and clinical complications in malaria patients

CSF (n=12)

10.27 (8.1-11.1)

609 (388–1059)

247.6 (119–343)

-

Plasma (n=62)

543.15 (401–837)

21126 (11590–33595)

28232 (22425–33418)

39.25 (23.14-62.56)

Fatal outcome

No (n=30)

591.36 (377.8-862.7)

14883 (9369–24849)

28232 (17288–33106)

30.55 (18.00-48.28)

Yes (n=32)

495.33 (401.0-825.2)

28215 (17040–42921)

28213 (22684–34395)

42.54 (30.57-70.07)

P-Value*

0.95

0.002

0.68

0.029

Hyper-parasitaemia

No (n=41)

688.94 (412–976)

18706 (11590–33565)

26013 (22684–34277)

31.26 (18.39-53.22)

Yes (n=21)

495.33 (377–615)

23863 (16110–34426)

28709 (22425–32990)

55.63 (41.60-69.26)

P-Value*

0.08

0.36

0.88

0.01

Jaundice

No (n=19)

459.77 (263–787)

9692 (7064–12949)

22907 (15334–29245)

21.94 (8.18-60.95)

Yes (n=43)

591.36 (401–963)

25041 (18288–41865)

28824 (22981–37659)

41.60 (30.17-63.16)

P-Value*

0.13

<0.0001

0.016

0.031

Anaemia

No (n=23)

495.33 (401–787)

12848 (9369–24519)

29245 (24960–33418)

28.10 (18.00-44.05)

Yes (n=39)

555.18 (377–988)

26565 (13657–41865)

23800 (19090–35373)

41.70 (30.55-71.30)

P-Value*

0.92

0.004

0.19

0.009

Acute renal failure

No (n=23)

495.33 (377–713)

11615 (8376–18706)

27908 (22684–32990)

30.10 (18.00-43.75)

Yes (n=39)

664.38 (401–988)

26788 (18288–43978)

28709 (21318–37659)

41.60 (30.17-69.26)

P-Value*

0.06

<0.0001

0.58

0.06

Hypoglycaemia

No (n=44)

567.21 (401–812)

18497 (9829–26217)

28805 (22907–34825)

31.60 (18.78-48.28)

Yes (n=18)

519.24 (377–963)

32948 (13657–45867)

23241 (19853–32679)

57.99 (37.34-85.16)

P-Value*

0.98

0.007

0.29

0.019

Shocked

No (n=38)

173.50 (401–988)

19932 (11590–31282)

28767 (22684–37659)

33.94 (18.78-56-24)

Yes (n=24)

459.77 (389–591)

24191 (11841–34918)

27699 (21817–31751)

43.62 (29.77-76.06)

P-Value*

0.053

0.36

0.48

0.13

Hyperlactataemia

No (n=39)

688.94 (401–988)

18706 (10415–33565)

27718 (21171–37659)

32.66 (22.77-59.84)

Yes (n=23)

495.33 (377–713)

24601 (12444–35352)

28786 (23501–32990)

43.48 (23.14-70.88)

P-Value*

0.14

0.36

0.69

0.2

Cerebral malaria

No (n=29)

495.33 (308–812)

21540 (13657–31021)

24960 (19090–37818)

41.60 (29.66-62.56)

Yes (n=33)

579.28 (436–850)

18706 (9692–34426)

28709 (22918–32990)

37.55 (20.65-63.61)

P-Value*

0.41

0.75

0.49

0.59

Pure cerebral malaria

No (n=54)

519.24 (377–837)

24191 (12848–34485)

28633 (22425–35373)

41.35 (29.66-66.28)

Yes (n=8)

713.50 (471–862)

7237 (5178–11321)

25407 (19415–29744)

8.18 (5.65-20.55)

P-Value

0.31

<0.0001

0.27

0.002