A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria

Table 4 Summary of correlations between plasma angiogenic markers and laboratory parameters

		Ang-1	Ang-2	Tie-2	Ang-2/Ang1 Ratio
Body temperature	rho, P-value*	0.2788, 0.029	ns	0.441, <0.0001
Body temperature	n	61		62
Haematocrit	rho, P-value*	ns	−0.368, 0.003	ns	ns
Haematocrit	n		62
Parasite count	rho, P-value*	ns	ns	ns	0.3, 0.018
Parasite count	n				61
Platelets	rho, P-value*	0.305, 0.018	−0.294, 0.022	ns	−0.442, <0.0001
Platelets	n		60		59
White blood cells	rho, P-value*	ns	0.471, <0.0001	ns	ns
White blood cells	n		59
BUN	rho, P-value*	ns	0.733, <0.0001	ns	0.554, 0.002
BUN	n		27		27
Creatinine	rho, P-value*	ns	0.619, <0.0001	ns	0.293, 0.02
Creatinine	n		62		61
Potassium (K)	rho, P-value*	ns	0.311, 0.027	ns	ns
Potassium (K)	n		50
SGOT	rho, P-value*	0.317, 0.014	0.415, 0.001	ns	ns
SGOT	n	59	60
SGPT	rho, P-value*	ns	0.283, 0.028	ns	ns
SGPT	n		50
TNF	rho, P-value*	0.416, 0.017	ns	ns	ns
TNF	n	32
Lactate	rho, P-value*	ns	ns	ns	ns
Lactate	n
Pyruvate	rho, P-value*	ns	ns	ns	ns
Pyruvate	n
PH	rho, P-value*	ns	−0.42, 0.004	ns	ns
PH	n		44
pCO2	rho, P-value*	ns	−0.4832, <0.0001	ns	−0.438, 0.003
pCO2	n		44		43
CSF Kynurenine	rho, P-value*	ns	ns	ns	ns
CSF Kynurenine	n
CSF Quinolinic Acid	rho, P-value*	ns	0.711, <0.0001	ns	0.625, <0.0001
CSF Quinolinic Acid	n		31		30
CSF Picolinic Acid	rho, P-value*	ns	0.753, <0.0001	ns	0.708, <0.0001
	n		31

*Spearman's rank correlation. No adjustments for multiple comparison have been made. All parameters were measured from plasma samples (except indicated as CSF) at time of admission. ns = not significant.

ISSN: 1475-2875