Figure 2

Associations between Plasmodium vivax parasitaemia and host biomarkers. (A) The distribution of P. vivax parasitaemia in different clinical groups is shown in red symbols (geometric means and 95% confidence intervals) whereas the values for network densities are shown as black bars. The variation of parasitaemia according to the malaria clinical severity was assessed using the Mann-Kendall test for linear trend (*** P<0.001). Statistically significant correlations between parasitaemia and different biomarkers are shown in (B) for the group of individuals with non-lethal severe malaria and in (C) for the group of patients that died during hospitalization. The correlations were assessed using the Spearman rank test. The correlations involving parasitaemia shown in (B) and (C) are plotted on top of the host interactome.