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Table 1 In vitro IC 50 of hybrids 1–3 against 3D7, D10 and Dd2 P. falciparum strains

From: Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

Compound

IC50(nM) ± SD

3D7

D10

Dd2

1

ND

14.9 ± 0.1

20.8 ± 3.6

2

20.5 ± 1.2

21.5 ± 0.1

25.7 ± 1.1

3

5.2 ± 0.7

14.3 ± 2.7

19.8 ± 0.3

DHA

ND

5.1 ± 0.6

2.1 ± 0.3

CQ

20 ± 1.6

21.5 ± 6.7

157.9 ± 52.7

  1. ND = not determined.