From: Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
Compound
IC50(nM) ± SD
3D7
D10
Dd2
1
ND
14.9 ± 0.1
20.8 ± 3.6
2
20.5 ± 1.2
21.5 ± 0.1
25.7 ± 1.1
3
5.2 ± 0.7
14.3 ± 2.7
19.8 ± 0.3
DHA
5.1 ± 0.6
2.1 ± 0.3
CQ
20 ± 1.6
21.5 ± 6.7
157.9 ± 52.7