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Table 2 Pharmacokinetic parameters of hybrid 2 after oral and IV administration

From: Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

Pharmacokinetic parameter

Hybrid 2

 

Mean ± SD (oral)

Mean ± SD (IV)

Cmax [ng/ml]

141 ± 56.8

ND

Tmax [min]

23.3 ± 5.8

ND

Apparent Terminal t½ [min]

3.9 ± 0.7

4.5 ± 1.2

AUC0-Inf [ng.min/ml]

3463 ± 895

112735 ± 125766

VD/F [L/kg]a

34 ± 10.8

0.4 ± 0.6

Plasma CL/F [L/min/kg]a

6.1 ± 1.8

0.06 ± 0.07

%BA

0.3 ± 0.1

ND

  1. a For the oral experiment, apparent oral CL and VD were reported; ND = not determined.
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Malaria Journal

ISSN: 1475-2875

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