Table 1 Anti-malarial activity of isolated and synthesized compounds against CQ-sensitive Plasmodium falciparum 3D7
Series BA | Series UA | ||
|---|---|---|---|
Compound | IC50 a(μM) | Compound | IC50(μM) |
BA | 18 ± 0.17 | UA | 36 ± 0.25 |
1a | > 100 | 2a | > 100 |
1b | 29 ± 0.26 | 2b | 71 ± 0.30 |
1c | 44 ± 0.14 | 2c | 72 ± 0.16 |
1d | 70 ± 0.19 | 2d | ND |
1e | 5 ± 0.14 | 2e | 7 ± 0.15 |
1f | 8 ± 0.16 | 2f | > 100 |
1g | 66 ± 0.25 | 2g | 58 ± 0.13 |
1h | 22 ± 0.17 | 2h | 58 ± 0.32 |
1i | > 100 | 2i | > 100 |
1j | ND | 2j | > 100 |