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Table 2 Inhibition of β-haematin formation

From: Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action

Compound

Concentration

Inhibitionb

IC50 c

CQ

(mM)

(%)

(mM)

indexa

Chloroquine

0.5 – 20

83 ± 1.07

3 ± 0.16

-

1e

0.5 – 19

25 ± 2.62

> 19

> 6.33

1f

0.5 – 20

14 ± 0.43

> 20

> 6.66

2e

0.5 – 19

26 ± 3.57

> 19

> 6.33

  1. a calculated as compound IC50/CQ IC50.
  2. b results are expressed as mean ± standard deviation at the highest tested concentration.
  3. c results are expressed as mean ± standard error.
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Malaria Journal

ISSN: 1475-2875

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