Table 1 Numbers of isolates carrying mutations at key positions in four anti-malarial resistance genes
From: Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan
Gene | Mutation examined | N | Mutated | (%) |
|---|---|---|---|---|
DHFR | A16V | 44 | 0 | (0) |
| Â | N51I | 44 | 0 | (0) |
| Â | C59R | 44 | 42 | (95.5) |
| Â | S108N | 44 | 44 | (100) |
| Â | I164L | 44 | 0 | (0) |
DHPS | S436A | 60 | 0 | (0) |
| Â | A437G/S | 57 | 8* | (14) |
| Â | K540E | 60 | 5 | (8.3) |
| Â | A581G | 60 | 8 | (13.3) |
| Â | A613S | 60 | 0 | (0) |
PFMDR1 | N86Y | 79 | 5 | (6) |
| Â | Y184F | 79 | 52 | (65.8) |
| Â | S1034C | 85 | 0 | (0) |
| Â | N1042D | 80 | 0 | (0) |
| Â | D1246Y | 43 | 0 | (0) |
| Â | Copy number** | 62 | 0 | (0) |
PFCRT | K76T | 49 | 49 | (100) |