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Table 1 Seroconversion and seroreversion rates for models based on AMA1, CelTOS and CSP

From: Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation

Antigen

Month of survey

Number of subjects (N = 882)

Seroconversion rate (95% CI)

Seroreversion rate (95% CI)

AMA1

February

294

0.144 (0.089, 0.235)

0.131 (0.057, 0.302)

 

May

294

0.074 (0.051, 0.108)

0.005 (0.000, 51.872)

 

August

294

0.078 (0.051, 0.118)

0.034 (0.005, 0.223)

§Total (AMA1)

  

0.095 (0.070, 0.129)

0.055 (0.022, 0.135)

CelTOS

February

294

0.026 (0.013, 0.054)

0.057 (0.005, 0.609)

 

May

294

0.027 (0.012, 0.059)

0.079 (0.010, 0.617)

 

August

294

0.020 (0.015, 0.027)

0.0000002 (0.00, 4718.9)

§Total (CelTOS)

  

0.023 (0.013, 0.041)

0.036 (0.002, 0.552)

CSP

February

294

λ1 = 0.226 (0.073, 1.700)

0.171 (0.093, 0.311)

  

*LRT: P < 0.01

λ2 = 0.022 (0.012, 0.040)

 
 

May

294

0.033 (0.014, 0.077)

0.132 (0.029, 0.595)

 

August

294

0.028 (0.014, 0.055)

0.054 (0.006, 0.512)

§Total (CSP)

*LRT: P < 0.01

λ1 = 0.319 (0.084, 1.219)

0.278 (0.166, 0.464)

   

λ2 = 0.024 (0.013, 0.044)

 
  1. Seroconversion and seroreversion rates are estimated from seroprevalence curves for each antigen (Figures 3 and 4).
  2. §Reversible catalytic model with standard error adjusted for clusters due to repeated cross-sectional sampling.
  3. *LRT represents likelihood ratio test of no change in seroconversion rate.