PROCR single nucleotide polymorphism detected in this study. A total of 23 PROCR SNPs were polymorphic in a sample set of 97 CHB subjects and 89 JPT subjects in the 1000 Genomes Project database. Two SNPs (rs867186 [Ser219Gly] and rs9574) indicated by solid lines were detected in a variation screening for seven malaria subjects. The PCR fragments investigated in this study are shown below the structure of the PROCR gene (NM_006404.3). The open and shaded boxes indicate UTR and coding regions, respectively. The numbers in the boxes indicate the exon number of the PROCR gene.