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Table 4 Quantification of fatty changes, hyperplastic Kupffer cells and portal inflammation in the livers of P. falciparum malaria patients compared with the control group

From: Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression

Histopathological changes

Normal liver (n = 10)

Non-hyperbilirubinaemia (TB < 51.3 μmol/L) (n = 10)

Hyperbilirubinaemia (TB ≥ 51.3 μmol/L) (n = 12)

Fatty changes (%/HPF)

0.59 ± 0.25

1.71 ± 0.46

1.97 ± 0.67

Hyperplastic Kupffer cells (count/HPF)

9.65 ± 0.67

32.05 ± 3.34a

52.21 ± 2.32a,b

Portal tract inflammation (%)

5.49 ± 1.20

17.1 ± 1.62a

32.79 ± 2.48a,b

  1. a Significant difference compared with normal controls, b Significant difference between malaria groups (p < 0.05 is considered statistically significant), Mann Whitney U-test.
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Malaria Journal

ISSN: 1475-2875

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