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Table 1 List of research projects grants awarded since the CRUN establishment in 2008

From: The impact of clinical research activities on communities in rural Africa: the development of the Clinical Research Unit of Nanoro (CRUN) in Burkina Faso

Year Title of the study/activity funded Funder
2008 Pharmacovigilance for Artemisinin-based combination treatments in Africa World Health Organization/(WHO/TDR)
Multi-drug resistance in malaria under combination therapy Assessment of specific markers and development of innovative, rapid and simple diagnostics (MALACTRES) European Union (FP7)
Pharmacokinetics of Mefloquine-Artesunate in Pregnant Women with Plasmodium falciparum infection Malaria in Pregnancy (MiP) Consortium
A Phase II multicenter, efficacy and safety study of parenteral SAR97276A Sanofi Aventis
2009 Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria European and Developing Countries Partnership (EDCTP)
Efficacy of GSK Biologicals. candidate malaria vaccine (257049)against malaria disease caused by P. falciparum infection in infants and children in Africa Malaria Vaccine Initiative (MVI)
Parallel group, double-blind, randomized study assessing the efficacy, safety and pharmacokinetic profile of ferroquine associated with artesunate Sanofi aventis
2010 Assessment of the Safety of Anti-malarial Drug Use During Early Pregnancy Malaria in Pregnancy (MiP) Consortium
Malaria risk prior to and during early pregnancy in nulliparous women receiving long-term weekly iron and folic acid supplementation National Institute of Health (NIH)
Epidemiology study of malaria transmission intensity in sub-Saharan Africa Malaria Vaccine Initiative (MVI)
Study of immune correlates of protection against malaria after vaccination with RTS, S/AS01E Malaria Vaccine Initiative (MVI)
Multi-methods study on Clinical Trial participation and the informed consent process in vulnerable populations Belgian cooperation
2011 Site characterization as a prelude to a study of malaria elimination using a combination of malaria control strategies in the Sahel region of Burkina Faso Malaria Capacity Development Consortium (MCDC)
Phase III randomized, open, controlled study to evaluate the immune response to the hepatitis B antigen of the RTS,S/AS01E candidate vaccine GlaxoSmithKline (GSK) Biologicals
Improved quality of diagnostic services for malaria in pregnancy World Health Organization/(WHO/TDR)
2012 Severe malaria and invasive bacterial disease among children: proportions, incidence rates and diagnostic value of Malaria Rapid Diagnostic Tests (ongoing) Institute of Tropical Medicine (Belgium Cooperation)
Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial in The Gambia, Burkina Faso and Benin European Union (EU FP7)
Genomic and environmental risk factors for cardio-metabolic disease in Africans. National Institute of Health (NIH)
2013 Study of the Incidence, Reservoir and Routes of Transmission of Invasive Salmonellosis in Burkina Faso (IRTIS -BF) Institute of tropical medicine (Belgium Cooperation)
An open-label, single-arm study to evaluate the efficacy, safety and PK of Artemether-Lumefantrine dispersible tablet in the treatment of acute uncomplicated Plasmodium falciparum malaria in infants <5 kg body weight Novartis
A phase II, open-label, multicentre, pharmacokinetic, pharmacodynamics and safety study of a new paediatric eurartesim dispersible formulation and crushed film coated eurartesim tablet, in infant patients with Plasmodium falciparum malaria Sigma Tau
Observational study to evaluate the clinical safety after introduction of the fixed-dose Artemisinin-based Combination Therapy Eurartesim® (dihydroartemisinin/piperaquine [DHA/PQP]) in public health districts in Burkina Faso, Mozambique, Ghana and Tanzania Indepth network