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Table 1 Definitions

From: Plasmodium falciparum clearance in clinical studies of artesunate-amodiaquine and comparator treatments in sub-Saharan Africa, 1999–2009

Measure Definition Population Analysis
Parasite clearance Patients’ conversion from a positive to a negative parasite slide within 7 days post-treatment start (independent of whether it was sustained throughout the entire duration of follow-up or there was a recurrent episode). All studies, whether comparative or not (n = 15,017) Observed median time of parasite clearance
Delayed parasite clearance - Parasitaemia positive on Prevalence, risks by multivariate analysis
o Day 2
o Day 3
Parasite clearance failure - Day 2 parasitaemia > pre-treatment parasitaemia
- Day 3 parasitaemia >25% pre-treatment parasitaemia
- Consecutive positive slides up to Day 7
Parasite reduction ratio Relative difference (referent: parasite before treatment) ASAQ groups (n = 2,355) where parasite densities were measured once daily from Days 0 to 3 and Day 7 Reduction rate
Predicted time of parasite clearance Modelling the time of parasite clearance   Predict the time of parasite clearance using the parasitaemia before treatment and the proportions of positive patients