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Table 1 Factors independently associated with the magnitude of antibody response by linear regression stepwise analysis

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

Antibody Antigen Variable Prop. diff1 95% CI P value2
IgG MSP-119 Previous infections 1.61 1.41; 1.84 < 0.0001
Current infections 1.39 1.74; 1.64 0.0001
Dry season 0.88 0.80; 0.97 0.0084
AMA-1 Previous infections 1.25 1.12; 1.40 0.0001
Current infections 1.23 1.08; 1.39 0.0019
Dry season 0.90 0.84; 0.97 0.005
EBA-175 Current infections 1.13 1.01; 1.27 0.0389
Congenital infections 1.29 1.10; 1.52 0.0017
IgG1 MSP-119 Previous infections 1.69 1.47; 1.95 0.0001
Current infections 1.31 1.18; 1.68 0.0002
Low birth weight 1.31 1.06; 1.63 0.0143
AMA-1 Previous infections 1.26 1.11; 1.43 0.0003
Current infections 1.29 1.11; 1.49 0.0007
Dry season 0.86 0.79; 0.93 0.0003
Placental infection 1.22 1.04; 1.43 0.0144
Congenital infections 1.31 1.06; 1.62 0.0128
EBA-175 Previous infections 1.13 1.03; 1.59 0.0105
Congenital infections 1.34 1.13; 1.24 0.0008
Dry season 0.88 0.82; 0.95 0.0008
IgG3 MSP-119 Previous infections 1.14 1.06; 1.24 0.0009
Current infections 1.54 1.38; 1.71 <0.0001
Intervention 1.11 1.03; 1.20 0.0068
Congenital infections 1.16 1.03; 1.30 0.0146
AMA-1 Previous infections 1.16 1.04; 1.29 0.0066
Current infections 1.34 1.17; 1.52 <0.0001
Placental inflammation 1.27 1.06; 1.53 0.0099
EBA-175 Current infections 1.14 1.04; 1.24 0.0008
Dry season 1.10 1.04; 1.16 0.0008
IgM MSP-119 Current infections 1.16 1.09; 1.25 <0.0001
Dry season 1.1 1.05; 1.15 <0.0001
AMA-1 Dry season 0.90 0.86; 0.94 <0.0001
  EBA-175 Dry season 1.07 1.03; 1.12 0.0009
  1. Models were adjusted for age and neighbourhood, which were also significantly associated with antibody levels (p < 0.0006).
  2. 1The proportional difference for a particular factor is the ratio between the average levels of antibodies in children with the factor vs children without the factor, adjusted for other variables in the model.
  3. 2P value using likelihood ratio test.