Skip to main content

Table 1 Factors independently associated with the magnitude of antibody response by linear regression stepwise analysis

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

Antibody

Antigen

Variable

Prop. diff1

95% CI

P value2

IgG

MSP-119

Previous infections

1.61

1.41; 1.84

< 0.0001

Current infections

1.39

1.74; 1.64

0.0001

Dry season

0.88

0.80; 0.97

0.0084

AMA-1

Previous infections

1.25

1.12; 1.40

0.0001

Current infections

1.23

1.08; 1.39

0.0019

Dry season

0.90

0.84; 0.97

0.005

EBA-175

Current infections

1.13

1.01; 1.27

0.0389

Congenital infections

1.29

1.10; 1.52

0.0017

IgG1

MSP-119

Previous infections

1.69

1.47; 1.95

0.0001

Current infections

1.31

1.18; 1.68

0.0002

Low birth weight

1.31

1.06; 1.63

0.0143

AMA-1

Previous infections

1.26

1.11; 1.43

0.0003

Current infections

1.29

1.11; 1.49

0.0007

Dry season

0.86

0.79; 0.93

0.0003

Placental infection

1.22

1.04; 1.43

0.0144

Congenital infections

1.31

1.06; 1.62

0.0128

EBA-175

Previous infections

1.13

1.03; 1.59

0.0105

Congenital infections

1.34

1.13; 1.24

0.0008

Dry season

0.88

0.82; 0.95

0.0008

IgG3

MSP-119

Previous infections

1.14

1.06; 1.24

0.0009

Current infections

1.54

1.38; 1.71

<0.0001

Intervention

1.11

1.03; 1.20

0.0068

Congenital infections

1.16

1.03; 1.30

0.0146

AMA-1

Previous infections

1.16

1.04; 1.29

0.0066

Current infections

1.34

1.17; 1.52

<0.0001

Placental inflammation

1.27

1.06; 1.53

0.0099

EBA-175

Current infections

1.14

1.04; 1.24

0.0008

Dry season

1.10

1.04; 1.16

0.0008

IgM

MSP-119

Current infections

1.16

1.09; 1.25

<0.0001

Dry season

1.1

1.05; 1.15

<0.0001

AMA-1

Dry season

0.90

0.86; 0.94

<0.0001

 

EBA-175

Dry season

1.07

1.03; 1.12

0.0009

  1. Models were adjusted for age and neighbourhood, which were also significantly associated with antibody levels (p < 0.0006).
  2. 1The proportional difference for a particular factor is the ratio between the average levels of antibodies in children with the factor vs children without the factor, adjusted for other variables in the model.
  3. 2P value using likelihood ratio test.