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Table 2 Levels of antibodies at the first episode of clinical malaria (acute) and one month later (convalescence) in relation to the levels of antibodies at the immediately preceding cross-sectional visit (pre-acute) in the three study groups

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

Antibody Antigen Pre-acute Acute Convalescent  
   GM1 GM Prop. diff.2 95% CI GM Prop. diff. 95% CI P value3
IgG MSP-119 0.47 0.73 1.56 1.20; 2.02 3.02 6.39 4.86; 8.40 < 0.0001
AMA-1 0.56 0.50 0.88 0.71; 1.09 1.01 1.80 1.44; 2.25 < 0.0001
EBA-175 0.53 0.41 0.77 0.65; 0.91 0.56 1.04 0.87; 1.24 < 0.0013
VSA 17.46 8.60 0.49 0.27; 0.91 11.58 0.64 0.39; 1.06 < 0.0398
IgM MSP-119 0.45 0.68 1.50 1.29; 1.73 0.67 1.47 1.26; 1.72 < 0.0001
AMA-1 0.39 0.44 1.11 0.99; 1.26 0.48 1.23 1.08; 1.39 < 0.0083
EBA-175 0.42 0.49 1.14 1.03; 1.26 0.51 1.18 1.06; 1.31 < 0.0046
IgG1 MSP-119 0.30 0.47 1.54 1.16; 2.04 2.32 7.48 5.54; 10.1 < 0.0001
AMA-1 0.37 0.31 0.82 0.65; 1.04 0.64 1.73 1.35; 2.22 < 0.0001
EBA-175 0.31 0.21 0.69 0.59; 0.81 0.27 0.87 0.74; 1.03 < 0.0001
IgG3 MSP-119 0.11 0.15 1.30 0.99; 1.70 0.49 4.36 3.28; 5.78 < 0.0001
AMA-1 0.14 0.13 0.93 0.77; 1.12 0.29 2.04 1.66; 2.50 < 0.0001
  EBA-175 0.11 0.07 0.61 0.52; 0.72 0.09 0.80 0.67; 0.95 < 0.0001
  1. 1Geometric means.
  2. 2The proportional difference is the ratio between the average levels of antibodies from acute (or convalescent) samples vs the levels from pre-acute samples, taking into account repeated measures for children.
  3. 3P value from Mixed-effects linear regression models using Likelihood Ratio Test.
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